衰老
间充质干细胞
再生医学
返老还童
移植
细胞生物学
生物
干细胞
细胞
表型
炎症
体外
癌症研究
免疫学
医学
内科学
遗传学
基因
作者
Pooi-Fong Wong,Murugan Dharmani Devi,Thamil Selvee Ramasamy
标识
DOI:10.1016/j.drudis.2022.103424
摘要
Mesenchymal stem cells (MSCs) are susceptible to replicative senescence and senescence-associated functional decline, which hampers their use in regenerative medicine. Senotherapeutics are drugs that target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence-associated secreted phenotype (SASP), respectively. Therefore, senotherapeutics could delay aging-associated degeneration. They could also be used to eliminate senescent MSCs during in vitro expansion or bioprocessing for transplantation. In this review, we discuss the role of senotherapeutics in MSC senescence, rejuvenation, and transplantation, with examples of some tested compounds in vitro. The prospects, challenges, and the way forward in clinical applications of senotherapeutics in cell-based therapeutics are also discussed.
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