m6A-induced ribosome stalling and collision trigger mRNA decay.

How m⁶A in different transcript regions regulates mRNA decay remains an intriguing question. Three studies from the labs of König,¹ Jaffrey,² and Steinmetz³ uncovered translation-dependent CDS-m⁶A decay: m⁶A in the coding sequence (CDS) induces ribosome stalling and collision to trigger mRNA decay, while tRNA modification alleviates the effects.