化学
烷基化
催化作用
烷基
基质(水族馆)
立体化学
组合化学
药物化学
分子
有机化学
海洋学
地质学
作者
Santu Mandal,Tripti Paul,Pallab Karjee,Monoj K. Barman,Tharmalingam Punniyamurthy
标识
DOI:10.1021/acs.orglett.3c02972
摘要
The site-selective C8-alkylation of quinolines has been accomplished using cyclopropyl alcohols as the alkylating agents and N-oxide as a weak chelating group in the presence of Co(III) catalysis via merging C–H/C–C bond activation. The use of cyclopropanol as the alkyl source, Co catalysis, substrate scope, HRMS analysis of the reaction intermediate, and late-stage mutation of drug molecules/natural products are the important practical features.
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