Impaired circadian rhythm may disturb epithelialization in the wound healing of the skin in diabetic mice

Organisms have an internal circadian clock entrained by environmental cues. In mammals, the suprachiasmatic nucleus, located in the anterior part of the hypothalamus, sets the timing of the body’s internal clock every morning by light signals from the retina [ [1] Patke A. Young M.W. Axelrod S. Molecular mechanisms and physiological importance of circadian rhythms. Nat. Rev. Mol. Cell Biol. 2020; 21: 67-84 Crossref PubMed Scopus (380) Google Scholar ]. Of note, the skin is governed by autonomous clock (as are other peripheral organs), as suggested by time-dependent variations of the skin barrier function [ 1 Patke A. Young M.W. Axelrod S. Molecular mechanisms and physiological importance of circadian rhythms. Nat. Rev. Mol. Cell Biol. 2020; 21: 67-84 Crossref PubMed Scopus (380) Google Scholar , 2 Yosipovitch G. Sackett-Lundeen L. Goon A. Yiong Huak C. Leok Goh C. Haus E. Circadian and ultradian (12h) variations of skin blood flow and barrier function in non-irritated and irritated skin-effect of topical corticosteroids. J. Invest. Dermatol. 2004; 122: 824-829 Abstract Full Text Full Text PDF PubMed Scopus (57) Google Scholar ].