A general averaging method for count data with overdispersion and/or excess zeros in biomedicine

With the aim of providing better estimation for count data with overdispersion and/or excess zeros, we develop a novel estimation method— optimal weighting based on cross-validation—for the zero-inflated negative binomial model, where the Poisson, negative binomial, and zero-inflated Poisson models are all included as its special cases. To facilitate the selection of the optimal weight vector, a [Formula: see text]-fold cross-validation technique is adopted. Unlike the jackknife model averaging discussed in Hansen and Racine (2012), the proposed method deletes one group of observations rather than only one observation to enhance the computational efficiency. Furthermore, we also theoretically prove the asymptotic optimality of the newly developed optimal weighting based on cross-validation method. Simulation studies and three empirical applications indicate the superiority of the presented optimal weighting based on cross-validation method when compared with the three commonly used information-based model selection methods and their model averaging counterparts.