The Essential Role of Immunomodulatory Tregs in Visual Deficits After Military-Relevant Trauma

Our studies suggest that depletion of Treg cells followed by blast injury leads to increased retinal degeneration and neuroinflammation. This highlights the continuous requirement of Foxp3 + Treg cell activity to prevent neurodegeneration in mTBI. Future studies should fully explore the relationship of immunomodulatory Treg cells with neurodegeneration in blast-associated visual deficits. Therapeutics aiming to modulate Treg cells could be tested in DEREG transgenic mice after blast injury.