Ferroelectric Heterojunction Membrane with Rapid Disinfection Through Coupling Piezoelectric and Pyroelectric Catalysis for Wound Regeneration

Abstract Ferroelectric materials with piezoelectric and pyroelectric properties have shown promise for antimicrobial therapy by generating reactive oxygen species (ROS) under external stimuli. However, the single catalytic approaches relying on either piezoelectric or pyroelectric effect compel ferroelectric materials to yield inadequate ROS, ultimately dampening the sterilization speed and efficiency. To address the daunting issue, a dual catalytic membrane composed of BaTiO 3 /MgO 2 and electrospun poly (lactic‐co‐glycolic acid) nanofibers is devised, which integrates both pyroelectric and piezoelectric effects of BaTiO 3 by encapsulating polydopamine. The dual catalytic membrane potentiates polarization charge generation under ultrasound and near‐infrared stimulation. Subsequently, the polarized charge participates in the generation of germicidal ·OH by reacting with H 2 O 2 from MgO 2 , thus achieving rapid antimicrobial activity. More intriguingly, in vitro and in vivo experiments have demonstrated that the dual catalytic membrane substantially facilitates cell proliferation and promotes the regeneration of infected wounds through bacterial slaughter, NF‐κB inflammatory pathway inhibition, pro‐angiogenesis, as well as collagen deposition. As envisaged, such a proposal provides a bright prospect for ferroelectric materials in addressing acute infections and advancing the remediation of refractory infected wounds.