眼泪
炎症
生物
体内
肩袖
免疫系统
微阵列
免疫学
基因表达
基因
遗传学
解剖
作者
Zhicheng Tong,Huimin Li,Yuqi Jin,Lingchao Sheng,Mingshuai Ying,Qixue Liu,Chenhuan Wang,Chong Teng
出处
期刊:Genomics
[Elsevier]
日期:2023-07-01
卷期号:115 (4): 110645-110645
被引量:2
标识
DOI:10.1016/j.ygeno.2023.110645
摘要
The processes driving ferroptosis and rotator cuff (RC) inflammation are yet unknown. The mechanism of ferroptosis and inflammation involved in the development of RC tears was investigated. The Gene Expression Omnibus database was used to obtain the microarray data relevant to the RC tears for further investigation. In this study, we created an RC tears rat model for in vivo experimental validation. For the additional function enrichment analysis, 10 hub ferroptosis-related genes were chosen to construct the correlation regulation network. In RC tears, it was discovered that genes related to hub ferroptosis and hub inflammatory response were strongly correlated. The outcomes of in vivo tests showed that RC tears were related to Cd68-Cxcl13, Acsl4-Sat1, Acsl3-Eno3, Acsl3-Ccr7, and Ccr7-Eno3 pairings in regulating ferroptosis and inflammatory response. Thus, our results show an association between ferroptosis and inflammation, providing a new avenue to explore the clinical treatment of RC tears.
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