材料科学
变性(医学)
椎间盘
纳米点
核心
上睑下垂
纳米技术
生物物理学
神经科学
细胞凋亡
解剖
医学
程序性细胞死亡
生物
病理
生物化学
作者
Kaiqiang Sun,Yan Chang,Xinyue Dai,Yangyang Shi,Fudong Li,Liang Chen,Jingchuan Sun,Yu Chen,Jiangang Shi
标识
DOI:10.1002/adma.202313248
摘要
Abstract Low back pain resulting from intervertebral disc degeneration (IVDD) is a prevalent global concern; however, its underlying mechanism remains elusive. Single‐cell sequencing analyses revealed the critical involvement of pyroptosis in IVDD. Considering the involvement of reactive oxygen species (ROS) as the primary instigator of pyroptosis and lack of an efficient intervention approach, this study developed carbonized Mn‐containing nanodots (MCDs) as ROS‐scavenging catalytic biomaterials to suppress pyroptosis of nucleus pulposus (NP) cells to efficiently alleviate IVDD. Catalytic MCDs have superior efficacy in scavenging intracellular ROS and rescuing homeostasis in the NP microenvironment compared with N‐acetylcysteine, a classical antioxidant. The data validates that pyroptosis plays a vital role in mediating the protective effects of catalytic MCDs against oxidative stress. Systematic in vivo assessments substantiate the effectiveness of MCDs in rescuing a puncture‐induced IVDD rat model, further demonstrating their ability to suppress pyroptosis. This study highlights the potential of antioxidant catalytic nanomedicine as a pyroptosis inhibitor and mechanistically unveils an efficient strategy for the treatment of IVDD. This article is protected by copyright. All rights reserved
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