纳米技术
生物相容性
药物输送
癌症治疗
纳米颗粒
癌症
材料科学
纳米医学
癌症治疗
靶向给药
医学
内科学
冶金
作者
Subham Preetam,Deb Duhita Mondal,Nobendu Mukerjee,Saleh A. Naser,Tanveer A. Tabish,Nanasaheb D. Thorat
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2024-03-01
标识
DOI:10.1021/acsbiomaterials.3c01540
摘要
Various nanomaterials have recently become fascinating tools in cancer diagnostic applications because of their multifunctional and inherent molecular characteristics that support efficient diagnosis and image-guided therapy. Zein nanoparticles are a protein derived from maize. It belongs to the class of prolamins possessing a spherical structure with conformational properties similar to those of conventional globular proteins like ribonuclease and insulin. Zein nanoparticles have gained massive interest over the past couple of years owing to their natural hydrophilicity, ease of functionalization, biodegradability, and biocompatibility, thereby improving oral bioavailability, nanoparticle targeting, and prolonged drug administration. Thus, zein nanoparticles are becoming a promising candidate for precision cancer drug delivery. This review highlights the clinical significance of applying zein nanosystems for cancer theragnostic─moreover, the role of zein nanosystems for cancer drug delivery, anticancer agents, and gene therapy. Finally, the difficulties and potential uses of these NPs in cancer treatment and detection are discussed. This review will pave the way for researchers to develop theranostic strategies for precision medicine utilizing zein nanosystems.
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