过氧化物
骨髓炎
对偶(语法数字)
双重角色
材料科学
植入
化学
医学
免疫学
外科
组合化学
艺术
文学类
有机化学
作者
Xin Yuan Guan,Si-Pei Wu,Sixue Ouyang,Shumei Ren,Naiqian Cui,Xiaohu Wu,Xiujuan J. Dai,Wenting Chen,Bin Yu,Peng Zhao,Bin Yu
标识
DOI:10.1002/adhm.202303529
摘要
Abstract Implant‐associated osteomyelitis (IAOM) is characterized by deep bone infection and progressive bone destruction, current therapy of long‐term high‐dose antibiotic treatment and radical surgical debridement often results in drug‐resistance and large bone defect. It is highly challenging to develop an antibiotic‐free, rapid bactericidal and osteogenic‐enhanced strategy for IAOM. Herein, we design an IAOM tailored anti‐bacterial and osteoinductive composite of Cu‐Sr peroxide nanoparticles (CSp NPs) encapulated in polyethylene glycol diacrylate (PEGDA) (CSp@PEGDA). The dual functional CSp NPs spontaneously displays in situ H 2 O 2 self‐supplying and Fenton‐catalytic Cu 2+ ions release, generating plenty of highly toxic hydroxyl radical (·OH) in a pH‐responsive manner for bacterial killing, while the released Sr 2+ promotes the in vitro osteogenicity regarding cell proliferation, alkaline phosphatase activity, extracellular matrix calcification, and osteo‐associated genes expression. The integration of Cu 2+ and Sr 2+ in synthesized CSp NPs together with the coated PEGDA hydrogel ensures the stable and sustainable ions release during short‐ and long‐term periods. Benefitted from the injectablity and photo‐crosslinkability, CSp@PEGDA is able to thoroughly fill the infectious site and rapidly gelate in situ for bacterial elimination and bone regeneration, which is successfully verified through in vivo evaluation using a clinical‐simulating IAOM mouse model. These favorable abilities of CSp@PEGDA precisely meet the multiple therapeutic needs and pave a promising way for implant‐associated osteomyelitis treatment. This article is protected by copyright. All rights reserved
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