胶质纤维酸性蛋白
脑脊液
医学
病理
脑膜炎
GFAP染色
甲基强的松龙
内科学
外科
免疫组织化学
作者
Yi Guo,Jiamin Guo,Xueyu Wang,Aihua Ma,Yuxing Gao,Jiacheng Chen,Chao Nie,Na Chen
出处
期刊:Heliyon
[Elsevier]
日期:2024-03-01
卷期号:10 (5): e26827-e26827
标识
DOI:10.1016/j.heliyon.2024.e26827
摘要
Glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune neurological disorder and is diagnosed by GFAP-IgG in cerebrospinal fluid (CSF) measurement.Herein, we described a 10-year-old boy with abnormal neurological symptoms and signs. GFAP-IgG was detected in CSF using cell-based assay (CBA), and his CSF showed an increase in lymphocytes, a slight decrease in glucose and an increase in protein level in the early stage. The cranial MRI showed multiple strips of T2-FLAIR hyperintense signal changes on the surface of medulla oblongata, pons, and gyrus in bilateral cerebral hemispheres. He was treated with immunoglobulin (IVIG) and high-dose methylprednisolone pulse treatment, and his clinical presentations gradually improved.We highlight that patients with normal inflammatory markers in peripheral blood have obvious meningitis-like symptoms, and clinicians need to consider GFAP astrocytopathy. The early diagnosis and treatment of GFAP astrocytopathy are important for improving the prognosis.
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