Design and Synthesis of Novel Chloropyridazine Hybrids as Promising Anticancer Agents Acting by Apoptosis Induction and PARP-1 Inhibition Through Molecular Hybridization Strategy

Guided by the molecular hybridization principle, a novel series of 4-chloropyridazinoxyphenyl conjugates (3a-h, 4a-e, and 5) was designed and synthesized as proposed apoptotic inducers and PARP-1 inhibitors. The growth inhibition...