化学
串联
催化作用
组合化学
2-吡啶酮
脚手架
有机化学
医学
生物医学工程
复合材料
材料科学
作者
Hyo Seon Sim,Hari Datta Khanal,Yong Rok Lee
标识
DOI:10.1021/acs.joc.2c01459
摘要
A highly efficient and atom-economic iron(III)-catalyzed three-component heteroannulation reaction between phenylpropiolamides, 3-formylchromones, and water is described for the construction of diversely multifunctionalized 2-pyridones. This protocol allows rapid access to a variety of 2-pyridones bearing an ortho-hydroxybenzoyl and a benzoyl scaffold under operationally simple conditions. The synthetic utility of the synthesized 2-pyridone scaffolds is demonstrated by transformation into biologically interesting complex heterocycles.
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