Precipitation-first synthesis and deep profiling of a 1200-member acrylamide library for covalent drug discovery
作者
Pravin Patil,Emis Ingenito,Riccardo Fusco,Imma Capriello,Z. L. Guan,Anuja Bhalkikar,John G. Gibbons,Tomas Korba,Stanislav Bashkyrtsev,О. В. Ткаченко,Alexander Dömlingꝉ
出处
期刊：Green Chemistry [The Royal Society of Chemistry] 日期：2025-01-01卷期号：27 (45): 14640-14647
We developed an efficient Ugi-based route to 1200 acrylamides, delivering millimolar quantities of pure precipitated products. Library quality was verified by 1H NMR, UPLC-UV-MS, and AEMS, yielding a sustainable drug-discovery-ready set.
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