生物
溶解循环
肠球菌
微生物学
噬菌体
毒力
噬菌体疗法
溶原循环
细菌
病毒学
遗传学
抗生素
基因
大肠杆菌
病毒
作者
Qian Chen,Zhewen Dong,Tingting Ding,Qilin Yang,Chang Liu,Fang Yin,Huanlong Qin
出处
期刊:PubMed
日期:2023-05-11
卷期号:: 199132-199132
标识
DOI:10.1016/j.virusres.2023.199132
摘要
Enterococcus gallinarum, a gut pathobiont, is an opportunistic pathogen that carries the risk of antibiotic resistance in the clinic and has been proven to drive autoimmunity in both mice and humans. Screening for novel bacteriophages targeting Enterococcus gallinarum is expected to provide a promising strategy for controlling such infections or regulating related chronic diseases. In the present study, we isolated a novel lytic Enterococcus gallinarum phage, Phi_Eg_SY1, which presents favourable thermostability and pH stability. Further assays indicated that Phi_Eg_SY1 can efficiently adsorb and lyse the host bacteria in vitro. Genomic and phylogenetic analyses suggested that Phi_Eg_SY1 does not contain virulence or lysogeny genes and presents a novel unassigned evolutionary lineage among the related dsDNA phages. Phi_Eg_SY1 is therefore considered to be suitable for further applications.
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