生物相容性
纳米材料
抗菌活性
木质素
纳米复合材料
纳米技术
材料科学
纳米颗粒
辐照
磁性纳米粒子
涂层
化学
化学工程
有机化学
细菌
遗传学
物理
生物
核物理学
工程类
冶金
作者
Daliane R.C. da Silva,Juan C. Scaiano
摘要
Given the current grave problems with antibiotic resistance, the discovery of novel, unconventional antibacterial drugs is not just important but also urgent. In this contribution, we report on the synthesis and testing of several composite nanomaterials that may find applications as therapeutic drugs or surface disinfectants. These materials are based on magnetic nanostructures coated with lignin, for example, lignin@FeCo. The magnetic properties of these nanocomposites facilitate removal or localization, whereas the lignin shell provides biocompatibility. These nanomaterials are mild antibacterials in the absence of light, but when illuminated become powerful antibacterial agents with typically ≥6 log units of bacterial reduction in 1–5 min of irradiation. These materials are strongly absorbing, including in the very useful NIR biological window, which we illustrate using 810 nm LED irradiation. We also show that in the short time required for antibacterial action, thermal changes are very small (≤5°C). Further, biocompatibility tests using fibroblasts show very limited cell damage and no enhanced adverse effect during 810 nm NIR illumination. As a surface coating for the active material, lignin provides a “trojan horse” strategy to facilitate the antibacterial action.
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