衰老
电离辐射
医学
辐射敏感性
放射治疗
癌症研究
纤维化
细胞凋亡
癌症
生物信息学
病理
内科学
生物
辐照
遗传学
核物理学
物理
作者
Hoang Q. Nguyen,Nhu Hanh To,Patricia Zadigue,Stéphane Kerbrat,Alexandre de la Taille,Sabine Le Gouvello,Yazid Belkacémi
标识
DOI:10.1016/j.critrevonc.2018.06.012
摘要
Ionizing radiation-exposure induces a variety of cellular reactions, such as senescence and apoptosis. Senescence is a permanent arrest state of the cell division, which can be beneficial or detrimental for normal tissue via an inflammatory response and senescence-associated secretion phenotype. Damage to healthy cells and their microenvironment is considered as an important source of early and late complications with an increased risk of morbidity in patients after radiotherapy (RT). In addition, the benefit/risk ratio may depend on the radiation technique/dose used for cancer eradication and the irradiated volume of healthy tissues. For radiation-induced fibrosis risk, the knowledge of mechanisms and potential prevention has become a crucial point to determining radiation parameters and patients’ intrinsic radiosensitivity. This review summarizes our understanding of ionizing radiation-induced senescent cell in fibrogenesis. This mechanism may provide new insights for therapeutic modalities for better risk/benefit ratios after RT in the new era of personalized treatments.
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