Copper-Catalyzed Carboxylation of C–F Bonds with CO2

An effective Cu-catalyzed selective formal carboxylation of C–F bonds with an atmospheric pressure of CO 2 is reported. A variety of gem -difluoroalkenes, gem -difluorodienes, and α-trifluoro-methyl alkenes show high reactivity and selectivity for this ipso monocarboxylation. Under mild conditions, diverse important α-fluoroacrylic acids and α,α-difluorocarboxylates are obtained in good-to-high yields. Moreover, this operationally simple protocol features good functional group tolerance, is readily scalable, and the resulting products are readily converted into bioactive α-fluorinated carbonyl compounds, indicating potential application in biochemistry and drug discovery. Mechanistic studies reveal that fluorinated boronate esters might be vital intermediates in this transformation.