脑脊液
医学
生物标志物
神经丝
病理
创伤性脑损伤
神经科学
生物信息学
生物
免疫组织化学
精神科
生物化学
作者
Lorenzo Gaetani,Kaj Blennow,Paolo Calabresi,Massimiliano Di Filippo,Lucilla Parnetti,Henrik Zetterberg
标识
DOI:10.1136/jnnp-2018-320106
摘要
In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases. New immunoassays able to detect biomarkers at ultralow levels have allowed for the measurement of NfL in blood, thus making it possible to easily and repeatedly measure NfL for monitoring diseases’ courses. Evidence that both CSF and blood NfL may serve as diagnostic, prognostic and monitoring biomarkers in neurological diseases is progressively increasing, and NfL is one of the most promising biomarkers to be used in clinical and research setting in the next future. Here we review the most important results on CSF and blood NfL and we discuss its potential applications and future directions.
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