光热治疗
吲哚青绿
阿霉素
透明质酸
药物输送
体内
化学
光热效应
纳米技术
生物医学工程
化疗
材料科学
医学
外科
生物技术
解剖
生物
作者
Lu Tang,Aining Zhang,Yijun Mei,Qiaqia Xiao,Xiaoli Xu,Wei Wang
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2021-12-13
卷期号:13 (12): 2145-2145
被引量:17
标识
DOI:10.3390/pharmaceutics13122145
摘要
The combinational application of photothermal therapy (PTT), chemotherapy, and nanotechnology is a booming therapeutic strategy for cancer treatment. Multi-walled carbon nanotube (MWNT) is often utilized as drug carrier in biomedical fields with excellent photothermal properties, and indocyanine green (ICG) is a near-infrared (NIR) dye approved by FDA. In addition, ICG is also a photothermal agent that can strongly absorb light energy for tumor ablation. Herein, we explored a synergistic strategy by connecting MWNT and a kind of ICG derivate ICG-NH2 through hyaluronic acid (HA) that possesses CD44 receptor targeting ability, which largely enhanced the PTT effect of both MWNT and ICG-NH2. To realize the synergistic therapeutic effect of chemotherapy and phototherapy, doxorubicin (DOX) was attached on the wall of MWNT via π-π interaction to obtain the final MWNT-HA-ICG/DOX nanocomplexes. Both in vitro and in vivo experiments verified the great therapeutic efficacy of MWNT-HA-ICG/DOX nanocomplexes, which was characterized by improved photothermal performance, strengthened cytotoxicity, and elevated tumor growth inhibition based on MCF-7 tumor models. Therefore, this synergistic strategy we report here might offer a new idea with promising application prospect for cancer treatment.
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