绞股蓝
达玛烷
皂甙
化学
立体化学
传统医学
糖苷
三萜
医学
色谱法
萃取(化学)
病理
替代医学
作者
Pham Thanh Ky,Pham Thanh Huong,Than Kieu My,Pham Tuan Anh,Phan Van Kiem,Chau Van Minh,Nguyen Xuan Cuong,Nguyen Phuong Thao,Nguyen Xuan Nhiem,Jae-Hee Hyun,Houyang Kang,Young Ho Kim
出处
期刊:Phytochemistry
[Elsevier]
日期:2010-06-01
卷期号:71 (8-9): 994-1001
被引量:35
标识
DOI:10.1016/j.phytochem.2010.03.009
摘要
Dammarane-type saponins, gypenosides VN1-VN7 (1-7), were isolated from the total saponin extract of Gynostemma pentaphyllum aerial parts, with their structures elucidated on the basis of spectroscopic and chemical methods. These compounds showed moderate cytotoxic activity against four human cancer cell lines, A549 (lung), HT-29 (colon), MCF-7 (breast), and SK-OV-3 (ovary), with IC(50) values ranging from 19.6+/-1.1 to 43.1+/-1.0 microM. Regarding the HL-60 (acute promyelocytic leukemia) cell line, compounds 1, 5, and 6 showed weakly active with IC(50) values of 62.8+/-1.9, 72.6+/-3.6, and 82.4+/-3.2 nM, respectively, while 2, 3, 4, and 7 were less active with IC(50) values>100 microM.
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