Prolonged Phrenic Nerve Blockade with Liposomal Bupivacaine

Editorial| April 2022 Prolonged Phrenic Nerve Blockade with Liposomal Bupivacaine Lei Xu, M.D.; Lei Xu, M.D. From the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California Search for other works by this author on: This Site PubMed Google Scholar Ban C. H. Tsui, M.D., M.Sc.; Ban C. H. Tsui, M.D., M.Sc. From the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California Search for other works by this author on: This Site PubMed Google Scholar Jean-Louis Horn, M.D. Jean-Louis Horn, M.D. From the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information Accepted for publication January 7, 2022. This editorial accompanies the article on p. 531. Michael J. Avram, Ph.D., served as Handling Editor for this article. Address correspondence to Dr. Horn: hornj@stanford.edu Anesthesiology April 2022, Vol. 136, 525–527. https://doi.org/10.1097/ALN.0000000000004160 Connected Content Article: Evaluation of Diaphragmatic Function after Interscalene Block with Liposomal Bupivacaine: A Randomized Controlled Trial Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Search Site Citation Lei Xu, Ban C. H. Tsui, Jean-Louis Horn; Prolonged Phrenic Nerve Blockade with Liposomal Bupivacaine. Anesthesiology 2022; 136:525–527 doi: https://doi.org/10.1097/ALN.0000000000004160 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll PublicationsAnesthesiology Search Advanced Search Topics: bupivacaine, liposomes, phrenic nerve In orthopedic shoulder surgery, obtaining optimal pain control extending beyond the immediate postoperative period is desired for better outcomes second to improved mobilization and analgesia. Interscalene nerve blocks are highly effective and widely used for postoperative pain management after shoulder surgery.1 However, they can be associated with unwanted side effects, including ipsilateral Horner’s syndrome, recurrent laryngeal nerve palsy, and phrenic nerve blockade. Of these complications, the incidence of phrenic nerve blockade approaches 100%. Phrenic nerve palsies are of interest due to the potential to cause hemidiaphragmatic paresis, which can lead to respiratory failure in those at risk.2,3 Additionally, in pursuit of longer anesthetic control beyond what can be obtained by the short-acting single-injection anesthesia, practitioners have been enticed to place nerve block catheters, add adjuvants to the local anesthetic solutions, or, more recently, use liposomal bupivacaine. Liposomal bupivacaine, a multivesicular drug delivery system, intended to create... You do not currently have access to this content.