Protection for the Amino Group

A great many protective groups have been developed for the amino group, including carbamates (>NCO2R), used for the protection of amino acids in peptide and protein syntheses, and amides (>NCOR), used more widely in syntheses of alkaloids and for the protection of the nitrogen bases adenine, cytosine, and guanine in nucleotide syntheses. In this chapter, detailed information is provided for the more useful protective groups (some of which are included in Reactivity Charts 8–10 in Chapter 10); structures and references are given for protective groups that seem to have more limited use.