化学选择性
化学
酮
组合化学
催化作用
炔烃
胺气处理
功能群
有机化学
烷基
锰
配体(生物化学)
生物化学
受体
聚合物
作者
Jimei Zhou,Min-xian Jia,Menghui Song,Zhiliang Huang,Alexander Steiner,Qidong An,Jianwei Ma,Zhiyin Guo,Jin Zhai,Huaming Sun,Craig M. Robertson,John Bacsa,Jianliang Xiao,Chaoqun Li
标识
DOI:10.1002/anie.202205983
摘要
Whilst allowing for easy access to synthetically versatile motifs and for modification of bioactive molecules, the chemoselective benzylic oxidation reactions of functionalized alkyl arenes remain challenging. Reported in this study is a new non-heme Mn catalyst stabilized by a bipiperidine-based tetradentate ligand, which enables methylene oxidation of benzylic compounds by H2 O2 , showing high activity and excellent chemoselectivity under mild conditions. The protocol tolerates an unprecedentedly wide range of functional groups, including carboxylic acid and derivatives, ketone, cyano, azide, acetate, sulfonate, alkyne, amino acid, and amine units, thus providing a low-cost, more sustainable and robust pathway for the facile synthesis of ketones, increase of complexity of organic molecules, and late-stage modification of drugs.
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