氧化应激
不育
男性不育
活性氧
氧化损伤
生理学
男科
精子
氧化磷酸化
医学
生物
内科学
细胞生物学
生物化学
遗传学
怀孕
作者
Amanda Mannucci,Flavia Rita Argento,Eleonora Fini,Maria Elisabetta Coccia,Niccoló Taddei,Matteo Becatti,Claudia Fiorillo
标识
DOI:10.3389/fmolb.2021.799294
摘要
At present infertility is affecting about 15% of couples and male factor is responsible for almost 50% of infertility cases. Oxidative stress, due to enhanced Reactive Oxygen Species (ROS) production and/or decreased antioxidants, has been repeatedly suggested as a new emerging causative factor of this condition. However, the central roles exerted by ROS in sperm physiology cannot be neglected. On these bases, the present review is focused on illustrating both the role of ROS in male infertility and their main sources of production. Oxidative stress assessment, the clinical use of redox biomarkers and the treatment of oxidative stress-related male infertility are also discussed.
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