大豆黄酮
传统医学
染料木素
雌激素受体
兴奋剂
生物活性
雌激素
化学
药理学
医学
受体
生物化学
内科学
体外
癌症
乳腺癌
作者
Kanae Ichikawa,Motomitsu Kitaoka,Motohiko Taki,Sachiko Takaishi,Yasuteru Iijima,Malee Boriboon,Tsuyoshi Akiyama
出处
期刊:Planta Medica
[Georg Thieme Verlag KG]
日期:1997-12-01
卷期号:63 (06): 540-543
被引量:45
标识
DOI:10.1055/s-2006-957759
摘要
Biological evaluation of the extract prepared from the stem wood of Dracaena loureiri, a Thai folkloric medicine called "Chan-daeng", revealed a significant capacity to inhibit [3H]-estradiol binding to the estrogen receptor. During the course of separation, two novel (1 and 2) and two known retrodihydrochalcones (3 and 4), in addition to three known homoisoflavones (5, 6, and 7), were isolated. The structures of compounds 1 and 2 were established by NMR and MS studies by correlating their spectroscopic properties with those of 3 and 4. Each isolate was assessed for its estrogenic activity. Compounds 1 and 6 exhibited activity comparable to that of genistein and daidzein.
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