胶束
纳米载体
阿霉素
材料科学
体内
药物输送
生物物理学
药品
化疗
癌症研究
药理学
化学
纳米技术
医学
水溶液
内科学
有机化学
生物
生物技术
作者
Seung Young Lee,Sung-Won Kim,Jacqueline Y. Tyler,Kinam Park,Ji‐Xin Cheng
出处
期刊:Biomaterials
[Elsevier]
日期:2013-01-01
卷期号:34 (2): 552-561
被引量:100
标识
DOI:10.1016/j.biomaterials.2012.09.065
摘要
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier made of disulfide (DS) bonded mPEG-(Cys)4-PDLLA micelles. Intravenously injected disulfide bonded micelles stably retained doxorubicin in the bloodstream and efficiently delivered the drug to a tumor, with a 7-fold increase of the drug in the tumor and 1.9-fold decrease in the heart, as compared with self-assembled (SA), non-crosslinked mPEG-PDLLA micelles. In vivo administration of disulfide bonded micelles led to doxorubicin accumulation in cancer cell nuclei, which was not observed after administration of self-assembled micelles. With a doxorubicin dose as low as 2 mg/kg, disulfide bonded micelles almost completely suppressed tumor growth in mice.
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