莫达非尼
清醒
斑马鱼
嗜睡症
神经科学
生物
睡眠(系统调用)
昼夜节律
药理学
脑电图
计算机科学
遗传学
基因
操作系统
作者
Benjamín Sigurgeirsson,Haraldur Þorsteinsson,Hrönn Arnardóttir,Ingibjörg þ. Jóhannesdóttir,Karl Karlsson
出处
期刊:Zebrafish
[Mary Ann Liebert]
日期:2011-09-01
卷期号:8 (3): 133-140
被引量:27
标识
DOI:10.1089/zeb.2011.0708
摘要
We describe, for the first time, the effects of the wakefulness-promoting drug modafinil on sleep and wakefulness in larval zebrafish. Modafinil is currently used to treat narcolepsy, hypersomnia, and shift-work disorder by increasing wakefulness. Tolerance and dependence are limited with modafinil use, differentiating it from common stimulants; however, the neural mechanisms of action of modafinil are still unknown. Zebrafish, a low-cost, prolific, and genetically tractable animal model, have recently become a key model in sleep research. Zebrafish express circadian rhythms, sleep homeostasis, and sleep pressure, and, in addition, respond to common hypnotics and stimulants in a manner similar to mammals. Therefore, in the current experiment we characterize the effects of modafinil on sleep–wake cycles in larval zebrafish as a first step to gaining further insight into the neural mechanisms underlying the effects of modafinil. We show that modafinil modulates sleep–wake activity in larval zebrafish in a manner consistent with what would be predicted from mammalian data. Modafinil increases wakefulness by lengthening wake-bouts, an effect that likely restricted to the night (lights-off). These results validate the use of zebrafish as an animal model for the study of sleep and provide a means for dissecting the neural mechanisms of modafinil, and, more broadly, sleep disorders.
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