Physical and Biological Properties of a Novel Hydrogel Composite Based on Oxidized Alginate, Gelatin and Tricalcium Phosphate for Bone Tissue Engineering

A novel hydrogel composite is reported in this study, which was derived from oxidized alginate, gelatin and tricalcium phosphate (TCP). The physical and biological properties of these hydrogel composites prepared with oxidized sodium alginate with different oxidation degrees were investigated. The drug delivery potential of this hydrogel composite as a carrier was evaluated by using Vitamin B2 as a model drug as well. An in vitro investigation with encapsulation of osteoblast revealed that these composites were biocompatible. This hydrogel composite presented here may be utilized for the fabrication of potential injectable systems for tissue engineering, drug delivery and other medical applications.