氢胺化
催化作用
化学
石油化工
烯烃
胺气处理
二氧化碳
有机化学
内酯
组合化学
作者
Arno Behr,Guido Henze,Leif Johnen,Sebastian Reyer
出处
期刊:Journal of Molecular Catalysis A-chemical
[Elsevier]
日期:2008-05-01
卷期号:287 (1-2): 95-101
被引量:34
标识
DOI:10.1016/j.molcata.2008.02.011
摘要
The atom economic hydroamination, the addition of an amine to an alkene, gained more and more importance as an “eco-friendly” alternative in amine synthesis. In this work the homogeneous catalytic 1,4-hydroamination of an unsaturated δ-lactone the 2-ethylidene-6-heptene-5-olide is investigated leading to a selective formation of an amino acid in a single step. The δ-lactone can be obtained by the telomerisation of the easily accessible 1,3-butadiene and the green house gas carbon dioxide. A new reactor concept is introduced which allows practical high-throughput catalyst screening with low costs. Variation of the metal precursors and the phosphorous ligands, optimisation of temperature and determinations of reaction rates leads to the catalyst system Al(OTf)3/DPEphos, which combines high activity (TOF = 846 h−1), no side products, low costs and low toxicity.
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