Absorption of glutathione from the gastro-intestinal tract

Transport of the peptide glutathione (GSH) has been studied with the rat small intestine in vitro and the human buccal cavity in vivo. Uptake was found to be sodium-independent in both systems. Saturation kinetics were demonstrated and uptake did not require energy in either system. Transport was inhibited by other small peptides. Carrier-mediated facilitated diffusion was postulated as the mode of transport.