合成生物学
生物生产
植物生物学
生物
代谢工程
系统生物学
生物技术
计算生物学
生化工程
工程类
遗传学
植物
基因
作者
Wusheng Liu,C. Neal Stewart
标识
DOI:10.1016/j.tplants.2015.02.004
摘要
•Plant synthetic biology is an emerging field of advanced genetic engineering driven by engineering principles. •Enabling tools include those for designing components and their assembly and deployment. •Pioneering examples are synthetic sensors, metabolic pathways, and plastids. Plant synthetic biology is an emerging field that combines engineering principles with plant biology toward the design and production of new devices. This emerging field should play an important role in future agriculture for traditional crop improvement, but also in enabling novel bioproduction in plants. In this review we discuss the design cycles of synthetic biology as well as key engineering principles, genetic parts, and computational tools that can be utilized in plant synthetic biology. Some pioneering examples are offered as a demonstration of how synthetic biology can be used to modify plants for specific purposes. These include synthetic sensors, synthetic metabolic pathways, and synthetic genomes. We also speculate about the future of synthetic biology of plants. Plant synthetic biology is an emerging field that combines engineering principles with plant biology toward the design and production of new devices. This emerging field should play an important role in future agriculture for traditional crop improvement, but also in enabling novel bioproduction in plants. In this review we discuss the design cycles of synthetic biology as well as key engineering principles, genetic parts, and computational tools that can be utilized in plant synthetic biology. Some pioneering examples are offered as a demonstration of how synthetic biology can be used to modify plants for specific purposes. These include synthetic sensors, synthetic metabolic pathways, and synthetic genomes. We also speculate about the future of synthetic biology of plants. the identification and establishment of hierarchies of functional units for the design process. an individual element/entity occurring in the composition of a biological object and contributing to its function. the imitation of the structures and functions of systems and elements of nature for the purpose of solving complex problems. the host organisms implemented with synthetic devices or gene networks. a functional unit rationally designed and assembled with synthetic parts for specific logical functions inside a cell or chassis. a biological device comprising heterogeneous parts. the breakdown of any object into simpler parts. the breaking down of complicated entities (systems, functions, or problems) into manageable, independent, and simpler constituents. functions arranged at different levels. functional independence of biological parts and devices. functionally equivalent and context-free properties of biological parts. an overlapping set of patent rights used to defend against competitors designing around a licensed patent. standard DNA sequences (such as promoters, coding sequences, and terminators) used as Lego-like building blocks for the design and assembly of synthetic biological devices in plants. a regulatory segment of a mRNA molecule that binds to its effectors, resulting in changes in its own activity. the definitive description and characterization of functionally equivalent and interchangeable (i.e., orthogonal) biological parts as well as the standardized conditions for construction and testing. information coming from different hierarchical levels.
科研通智能强力驱动
Strongly Powered by AbleSci AI