Magnetic particle spectroscopy characterization of the assemblies of magnetic nanoparticles

Summary form only given. This research focuses on the design of magnetic nanoparticles particles (MNPs) and their assemblies for specific applications in biomedicine, combining high functional activity as drug and gene delivery vectors and sufficient magnetic responsiveness to make magnetic targeting feasible. The resulting materials should be also suitable as magnetic particle imaging (MPI) and magnetic resonance imaging (MRI) tracer. MPS measurements were carried out for tailor-made magnetic nanoparticles selected for cell labeling, assembling of magnetic delivery non-viral and viral vectors. Another aspect of the investigation is to understand how cellular confinement and clustering of the MNPs and their assemblies in labeled or magnetofected cells influence the magnetic behavior of the particles and the output signal in MPS. In particular, internalization of SO-Mag5 nanoparticles in HUVEC has not changed the MPS output. Understanding the role of nanointeractions in tracer characteristics is of importance for design of efficient magnetic vectors for targeting of theragnostics with optimized performance in MPI.