The aim of our study was to investigate the effect of antihypertensive treatment on erectile function in patients with essential hypertension. From our hypertension outpatient clinic, 358 consecutive young and middle-aged men (31–65 years old, 49.1±5.2 years) with essential hypertension filled a questionnaire regarding erectile function (International Index for Erectile Function). Antihypertensive therapy significantly affected the erectile function of our patients, with patients on combination therapy exhibiting the higher prevalence of erectile dysfunction. Older antihypertensive drugs exhibit worse profile on erectile function than newer drugs, suggesting that this may be another parameter for the proper choice of antihypertensive drug.