CALCIUM ANTAGONISTS IN ARTERIAL HYPERTENSION TREATMENT: SPECIFICS OF LERCANIDIPINE

Lercanidipine is a dihydropyridine calcium antagonist of the 3rd generation, with high level of vasoselectivity, long lasting effect and good antihypertensive effectiveness. The review shows the main specifics of pharmacokinetics and mechanism of action of the drug. It is known that lercanidipine supports renoprotection, left ventricle hypertrophy reduction, improvement of elastic properties of the vessels and central blood pressure decrease. Sympathetic activation in lercanidipine is almost absent, that makes up its good tolerability and improves patients’ compliance.