白花丹
硫氧还蛋白还原酶
活性氧
硫氧还蛋白
细胞凋亡
化学
氧化应激
萘醌
癌细胞
生物化学
谷胱甘肽
细胞生物学
药理学
生物
癌症
酶
植物
有机化学
遗传学
作者
Junmin Zhang,Shoujiao Peng,Xinming Li,Ruijuan Liu,Xiao Han,Jianguo Fang
标识
DOI:10.1016/j.abb.2017.02.007
摘要
Plumbagin (PLB), a natural naphthoquinone from the traditional folk medicines Plumbago zeylanica, Dionaea muscipula, or Nepenthes gracilis, has been documented possessing a wide variety of pharmacological activities. Although PLB demonstrates anticancer activity in multiple types of malignant cells, the cellular targets of PLB have not been well defined and remained only partially understood. We reported here that PLB selectively inhibits TrxR and elicits reactive oxygen species in human promyelocytic leukemia HL-60 cells, which leads to elevation of GSSG/GSH ratio and decrease of cellular thiol pool. As a consequence, PLB disturbs the cellular redox homeostasis, induces oxidative stress-mediated apoptosis and eventually selectively kills HL-60 cells. Inhibition of TrxR by PLB thus discloses an unprecedented mechanism underlying the anticancer efficacy of PLB, and sheds light in considering the usage of PLB as a promising cancer therapeutic agent.
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