丝素
光动力疗法
伤口愈合
黑色素瘤
材料科学
再生(生物学)
自愈水凝胶
巨噬细胞
癌症研究
医学
丝绸
生物
化学
免疫学
体外
细胞生物学
高分子化学
有机化学
复合材料
生物化学
作者
Xiaoxuan Tang,Xiaoli Chen,Siming Zhang,Xinyi Gu,Ronghua Wu,Tingting Huang,Zhihao Zhou,Cheng Sun,Jue Ling,Mei Liu,Yumin Yang
标识
DOI:10.1002/adfm.202101320
摘要
Abstract Easy cancer recurrence and wound infections have been clinical challenges after surgical treatment of melanoma. Herein, a silk‐inspired in situ gelation system containing methacrylated silk fibroin (SF) and chlorine e6 for improved cancer therapy with enhanced wound healing is developed. Favored by the macrophage recruitment capacity of the SF hydrogel, promising antitumor immune responses can be turned “on” via near infrared irradiation in a controllable manner to achieve combination therapy with photodynamic therapy to significantly suppress melanoma recurrence. Moreover, the effective photodynamic antibacterial activity of this bioactive system with the capacity of light‐controllable modulating macrophage phenotype promotes remarkable tissue ingrowth with hair follicle regeneration for Staphylococcus aureus infected wound healing. Thus, this multifunctional silk‐based hydrogel system, as a desirable wound dressing, provides a new platform for promising melanoma therapy and skin regeneration.
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