壳聚糖
伤口愈合
静电纺丝
纳米纤维
消毒剂
乳酸
化学
抗菌活性
材料科学
聚合物
复合材料
外科
有机化学
细菌
医学
遗传学
生物
作者
Yangmei Ren,Lanmei Huang,Yuelong Wang,Mei Lan,Rangrang Fan,Min He,Chao Wang,Aiping Tong,Haifeng Chen,Gang Guo
标识
DOI:10.1016/j.carbpol.2020.116754
摘要
Skin damage, especially the extensive full-thickness wound, is seriously affecting people’s daily life and health. Meanwhile, wound healing is always challenged by bacterial infection. In this study, for the purpose of developing a disinfectant wound dressing, we designed a novel multi-functional nanofiber mats via electrospinning combining chitosan derivations and stereocomplex crystallite (SC). The SC membrane of poly (lactic acid)/chitosan derivatives were prepared via warming at 80 °C for 1 h. The thermal and mechanical properties of the heated mats were strengthened owing to the formation of SC, which restricted the lactide chains mobility. In vivo wound healing test revealed that the SC mats have better wound repair ability than the control group with a wound healing rate of 100 % within 15 days. In a word, the biomass-based mats with enhanced thermal and mechanical properties, antibacterial effect and antioxidant activity, providing a potential multi-functional platform for designing of disinfectant wound dressings.
科研通智能强力驱动
Strongly Powered by AbleSci AI