化学
体内
荧光
纤维化
内生
心肌纤维化
一氧化氮
光诱导电子转移
生物物理学
纳米技术
电子转移
内科学
生物化学
光化学
生物
物理
生物技术
有机化学
医学
材料科学
量子力学
作者
Tongliang Zhou,Junda Wang,Jiamin Xu,Cangxin Zheng,Yan Niu,Chao Wang,Fengrong Xu,Lamei Yuan,Xin Zhao,Liang Liu,Ping Xu
标识
DOI:10.1021/acs.analchem.9b05435
摘要
On the basis of the pyridazinone scaffold and photoinduced electron transfer (PET) mechanism, we designed a smart nitric oxide (NO) probe, PYSNO, with high sensitivity and selectivity. PYSNO exhibited a rapid response to both exogenous and endogenous NO. This probe can also be used in tracking and investigating NO generation in animal tissue. In the myocardial fibrosis model for mice, PYSNO exhibited a powerful imaging property in vivo as a result of unravelling the progressive relationship between the generation of myocardial NO and the occurrence of myocardial fibrosis.
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