化学
催化作用
衍生工具(金融)
组合化学
铑
有机化学
金融经济学
经济
作者
Nengjian Cai,Fen Mi,Yanmei Wu,Hao Song,Xiaoyu Liu,Yong Qin
标识
DOI:10.1016/j.tetlet.2019.151498
摘要
An efficient three-step sequence has been developed for the preparation of a chiral 4-bromotryptophan derivative starting from the commercially available 4-bromoindole. Key to the synthesis was the generation of the chiral center via a Rh-catalyzed asymmetric hydrogenation of a dehydrotryptophan precursor with 95% yield and >99% ee. Notably, the whole synthetic route required no column chromatographic operations and was readily conducted on large scales.
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