循环肿瘤细胞
转移
医学
癌症
癌症研究
人口
内科学
环境卫生
作者
Mert Boya,Chia‐Heng Chu,Ruxiu Liu,Tevhide Ozkaya‐Ahmadov,A. Fatih Sarioglu
出处
期刊:Recent results in cancer research
日期:2019-10-12
卷期号:: 25-55
被引量:16
标识
DOI:10.1007/978-3-030-26439-0_2
摘要
Circulating tumor cells (CTCs) are responsible for the metastatic spread of cancer and therefore are extremely valuable not only for basic research on cancer metastasis but also as potential biomarkers in diagnosing and managing cancer in the clinic. While relatively non-invasive access to the blood tissue presents an opportunity, CTCs are mixed with approximately billion-times more-populated blood cells in circulation. Therefore, the accuracy of technologies for reliable enrichment of the rare CTC population from blood samples is critical to the success of downstream analyses. The focus of this chapter is to provide the reader an overview of significant advances made in the development of diverse CTC enrichment technologies by presenting the strengths of individual techniques in addition to specific challenges remaining to be addressed.
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