Bosentan,a dual endothelin receptor antagonist

Bosentan is a specific competitive dual endothelin receptor antagonist of low molecular weight. It inhibits ET-1 action through combination with both ETA and ETB receptors. It is indicated to treat type Ⅲ and Ⅳ pulmonary hypertension in WHO functional group. The pharmacology, pharmacokinetics,and clinical applications of bosentan are reviewed in this paper.