硝苯地平
医学
安慰剂
置信区间
临床试验
比例危险模型
安慰剂组
内科学
相对风险
麻醉
心脏病学
病理
替代医学
钙
作者
Liang Gong,Weizhong Zhang,Yijun Zhu,Jun Zhu,Dewen Kong,Véronique Pagé,Parviz Ghadirian,Jacques LeLorier,Pavel Hamet
标识
DOI:10.1097/00004872-199610000-00013
摘要
To assess the effectiveness of nifedipine treatment in elderly hypertensives.A single-blind trial was conducted under the direction of the Shanghai Institute of Hypertension in 1632 subjects aged 60-79 years alternatively allocated to either nifedipine or placebo after a 4-week placebo run-in period between 1987 and 1990 with mean follow-up of 30 months. Clinical events and risk modification were analysed in collaboration with the University of Montreal. Seventy-four patients with severe hypertension were reallocated to active nifedipine treatment after placebo run-in.Cox's proportional hazards model accounting for covariates demonstrated a highly significant decrease in the probability of events: 'original treatment assignment' analysis indicated that 77 events occurred in the placebo and 32 in the nifedipine group. Similar significances were achieved with 'actual treatment' or 'changes excluded' (excluding reallocated subjects) analyses. A significant reduction in relative risk was observed for strokes and severe arrhythmia with an overall decrease from 1.0 to 0.41 (95% confidence interval 0.27-0.61).Nifedipine treatment diminished the number of severe clinical outcomes in elderly hypertensives significantly.
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