Randomized and open control study for amisulpride and ziprasidone in treatment of schizophrenia

Objective: To compare efficacy and adverse reactions of amisulpride and ziprasidone in treatment of schizophrenia.Methods: 78 adult cases of schizophrenia meeting the diagnostic criteria were randomly assigned to amisulpride group(n = 38)(orally taking amisulpride for 8 weeks) and ziprasidone group(n = 40)(orally taking ziprasidone for 8 weeks).The efficacy and adverse reactions were evaluated with PANSS and TESS before and 2,4,and 8 weeks after the treatment.Results: After the treatment,the scores of PANSS in both groups decreased significantly compared with the baseline(P 0.05).Both group had fewer adverse reactions.Conclusions: Amisulpride and ziprasidone are safe and effective in the treatment of schizophrenia,however,amisulpride is better than ziprasidone for treating depress symptoms.