Objective To observe the curative effect of Triamcinolone acetonide combined with ratinoic acid treating keloid. Methods 55 cases of keloid patient were devided into two group randomly, treatment group and control group.The treatment group composed by 29 keloid patients was treated with Triamcinolone acetonide and ratinoic acid; The control group by 25 keloid patients was treated with Triamcinolone acetonide only. Results The curative rate and total efficacy rate of treatment group was 58.62% and 93.11% respectively, while which of control group was 26.92% and 73.07%. The curative rate and total efficacy rate between two groups were significantly different. Conclusion The method of local blockage with Triamcinolone acetonide conbined with ratinoic acid was effective in treating keloid.