伤害
延髓头端腹内侧区
神经科学
导水管周围灰质
认知
5-羟色胺能
慢性疼痛
医学
髓质
痛觉
心理学
痛觉过敏
认知心理学
中枢神经系统
麻醉
血清素
解剖
中脑
受体
内科学
作者
Milena De Felice,Michael H. Ossipov
出处
期刊:Pain management
[Future Medicine]
日期:2016-04-01
卷期号:6 (2): 111-120
被引量:41
摘要
Pain is more than merely nociception and response, but rather it encompasses emotional, behavioral and cognitive components that make up the pain experience. With the recent advances in imaging techniques, we now understand that nociceptive inputs can result in the activation of complex interactions among central sites, including cortical regions that are active in cognitive, emotional and reward functions. These sites can have a bimodal influence on the serotonergic and noradrenergic descending pain modulatory systems via communications among the periaqueductal gray, rostral ventromedial medulla and pontine noradrenergic nuclei, ultimately either facilitating or inhibiting further nociceptive inputs. Understanding these systems can help explain the emotional and cognitive influences on pain perception and placebo/nocebo effects, and can help guide development of better pain therapeutics.
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