增生性瘢痕
炎症
医学
病理
H&E染色
免疫组织化学
中枢神经系统
神经系统
神经组织
背
解剖
免疫学
内科学
精神科
作者
Shaohua Li,Heng-lian Yang,Hu Xiao,Yibing Wang,Dechang Wang,Ran Huo
标识
DOI:10.4103/1673-5374.167769
摘要
This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation.
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