A Review on Sustained Release Drug Delivery System

Among all drug delivery systems, oral drug delivery is the most preferred route for administration for various drugs. Availability of wide variety of polymers and frequent dosing intervals helps the formulation scientist to develop sustained/controlled release products. Oral sustained release (SR)/Controlled release (CR) products provide an advantage over conventional dosage forms by optimizing bio-pharmaceutics, pharmacokinetic and pharmacodynamic properties of drugs. It also reduces dosing frequency to an extent that once daily dose is sufficient for therapeutic management through which uniform plasma concentration providing maximum utility of drug with reduction in local and systemic side effects and cure or control condition in shortest possible time by smallest quantity of drug to assure greater patient compliance. Sustained Release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body.