跨膜蛋白
随机六聚体
AAA蛋白
生物
细胞生物学
膜蛋白
胞浆
跨膜结构域
生物化学
蛋白酶
酶
ATP酶
效应器
膜
受体
作者
Koreaki Ito,Yoshinori Akiyama
出处
期刊:Annual Review of Microbiology
[Annual Reviews]
日期:2005-10-01
卷期号:59 (1): 211-231
被引量:368
标识
DOI:10.1146/annurev.micro.59.030804.121316
摘要
FtsH is a cytoplasmic membrane protein that has N-terminally located transmembrane segments and a main cytosolic region consisting of AAA-ATPase and Zn2+-metalloprotease domains. It forms a homo-hexamer, which is further complexed with an oligomer of the membrane-bound modulating factor HflKC. FtsH degrades a set of short-lived proteins, enabling cellular regulation at the level of protein stability. FtsH also degrades some misassembled membrane proteins, contributing to their quality maintenance. It is an energy-utilizing and processive endopeptidase with a special ability to dislocate membrane protein substrates out of the membrane, for which its own membrane-embedded nature is essential. We discuss structure-function relationships of this intriguing enzyme, including the way it recognizes the soluble and membrane-integrated substrates differentially, on the basis of the solved structure of the ATPase domain as well as extensive biochemical and genetic information accumulated in the past decade on this enzyme.
科研通智能强力驱动
Strongly Powered by AbleSci AI